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Dutasteride-Tamsulosin or dutasteride have been historically prescribed as 0.5 mg capsule/day for management of symptoms of bph and enlarged prostate. In clinical trials, oral dutasteride capsules have been successful in reducing hair loss and promoting new hair growth. In one study, ninety men with androgenetic alopecia were randomly assigned to either a finasteride or a dutasteride group. Men between 18 and 40 years of age either received 0.5mg dutasteride or 1mg finasteride daily for 24 weeks. Hair counts at the start of the study and at the 24 week follow-up were measured in total hair counts per cm².
Study design
In clinical studies, finasteride has been shown to be effective in reducing hair loss in the majority of men who use it. When dutasteride is used to treat male pattern hair loss, the before and after effects can be quite noticeable. Dutasteride has been shown to be effective in treating female pattern hair loss. A before and after picture of a woman who used dutasteride can provide visual evidence of the results that can be achieved with this medication.
Effect of Treatment with Dutasteride (Oral or Intralesional) on Hair Count
After three to four months of usage, many men who take finasteride see slight improvements; nevertheless, “final” outcomes from finasteride therapy often take about a year to manifest21. Follicular miniaturization is a gradual process that can take years to become noticeable. It typically starts in the frontal hairline or crown of the scalp and progresses to other areas of the scalp over time. A 30-day supply of spironolactone costs $2.19, and oral finasteride costs $4.63 for 30 tablets.
Does Dutasteride increase estrogen levels?
For instance, a 2017 study found that females who took 0.25 milligrams (mg) of oral minoxidil and 25 mg of spironolactone as daily capsules saw an improvement in FPHL. Most of the common side effects of dutasteride and finasteride are sexual. If you’re definitely interested in trying topical dutasteride, you’ll likely be safest if you join a clinical trial. If you’re not eligible or living in the region where the trial is taking place, consider another topical hair loss treatment.
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Make sure to check with your doctor about any drug interactions before beginning dutasteride treatment to ensure your safety. Only RCT assessing the effect of either intralesional or oral dutasteride compared with a respective placebo, as well as RCT directly comparing the efficacy of oral versus intralesional dutasteride, were included. To be considered for inclusion, each study must have had a minimum follow-up of 8 weeks. There was no restriction regarding language, dose, and number of interventions in each group. We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle.
Sometimes a larger strip of skin containing multiple hair groupings is taken. This procedure doesn't require hospitalization, but it is painful so you'll be given a sedation medicine to ease any discomfort. If your hair loss is caused by an underlying disease, treatment for that disease will be necessary.
Is Dutasteride the Best Treatment for Male Hair Loss?
Laser therapy has been shown to be an effective treatment for hair loss, with clinical studies demonstrating an increase in hair density and hair count in patients using laser therapy. Men with male pattern baldness who have a medical prescription from a healthcare provider, can safely use both medications, finasteride and dutasteride. Male androgenetic alopecia (also known as male pattern baldness) is a common type of hair loss that affects 30-50% of men by age 50.
Taking or touching the medication while pregnant can expose a developing fetus to the drug and cause harmful effects. People with a history of an allergic reaction to dutasteride or finasteride should avoid these products. Some people prefer to try herbal remedies for prostate health before pursuing prescription treatments. Some evidence suggests that saw palmetto and African cherry might benefit men with mild BPH symptoms and improve urinary symptoms. If you stop taking finasteride, the effects of the drug wear off within two weeks. By lowering DHT levels, finasteride helps to reduce prostate enlargement.
This is because the topical medication may come with a reduced risk of sexual dysfunction. However, the topical form may cause irritation, a burning sensation, or contact dermatitis at the treatment site. It works by binding to the 5-alpha reductase enzyme and stopping it from converting testosterone into dihydrotestosterone (DHT). According to 2021 research, experts believe it shortens the hair’s resting phase — called the telogen phase — and extends the growth phase, called the anagen phase. Both drugs can cause sexual side effects, but dutasteride might have a slightly higher risk. Interactions with other drugs can affect how well these medications work or increase the risk of side effects.
Because of its ability to dramatically reduce DHT levels, dutasteride is often considered one of the strongest hair loss treatments for male prn baldness in the world, even though it has not been FDA-approved for that use. Its long half-life (compared to finasteride) may allow for less than daily dosing once a steady state is reached. However, concerns about rare side effects and especially dutasteride’s tendency to “linger” in the body due to its long half-life are a concern for many patients and physicians who may prescribe this off-label treatment. Doctors often prescribe oral medications to be used along with topical minoxidil because studies show the combination boosts hair production.
By the age of 70 or beyond, 80% of Caucasian men and up to 40% of women have signs of AGA [2, 3]. The main pathological mechanism of AGA fundamentally involves the local and systemic conversion of testosterone to dihydrotestosterone (DHT) by the enzyme 5-α-reductase (5 aR). In the current study, improvement in AGA was defined as a decrease in BASP classification of hair loss.
Hair Loss Drugs Ranked in Order of Efficacy - Medpage Today
Hair Loss Drugs Ranked in Order of Efficacy.
Posted: Mon, 07 Feb 2022 08:00:00 GMT [source]
Hair loss, or alopecia, affects more than 80 percent of men and 50 percent of women, and the risk increases with age. Our capsules generally come in the 0.6mg strength, and our topical formulation can be compounded with up to 1mg of Dutasteride per gram. You can have a free online minute questionnaire-based appointment with our doctors today to see if Dutasteride is a good choice for you. Some medications, such as finasteride and spironolactone, are only available with a doctor’s prescription. Below are answers to some of the top questions about hair loss medications. The table below compares each of the hair loss medications in this article.
If a female, child, or adolescent comes into contact with the inside of the medication, they must wash their hands immediately. Dutasteride may also interact with certain medications a person is already taking. If any of the above side effects are severe, a person should inform a doctor. Doctors only prescribe finasteride to treat type 2, whereas dutasteride can treat both types. Dutasteride also decreases a person’s risk of developing urinary retention, which is the inability to urinate. The bottom line is that concerns about fertility should be discussed with your physician before starting any anti-androgen medication like dutasteride.
It typically isn’t covered by insurance, and it can be expensive, Mirmirani says. A large body of research has shown that these over-the-counter creams and foams, applied to the scalp daily, are effective at stimulating hair growth, increasing hair density and halting hair loss over time. Research estimates that approximately 50% of males and females experience hair loss, the most common type being androgenetic alopecia. Hair loss can affect anyone regardless of age, sex, hair color, and type.
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